EFFECT OF TOPOGRAPHY, MECHANICAL PROPERTIES AND SHEAR STRESS ON CELL RESPONSES FOR TISSUE ENGINEERING APPLICATIONS
Event Dates
From: 03/11/2021 12:00
To: 03/11/2021 14:00
Speaker(s)
Place
Online Zoom Platform: https://us02web.zoom.us/j/84365015631?pwd=RG4rTHFQelNFelJKMHh1dHFCYkNpdz09

Understanding the mechanisms by which the topographical cues of extracellular matrix (ECM) affect cellular responses (proliferation, adhesion, growth, orientation, and differentiation) is fundamentally important for tissue engineering / regenerative medicine applications. Although a growing body of literature supports that the substrate’s topography influences the cell proliferation and differentiation, the underlying cellular and molecular mechanisms are poorly understood. In our attempt to approach this issue we study the cell response dependence on tunable topography, mechanical properties and defined chemistry. Our experimental findings also indicate that depending on the relation of the direction of flow with respect to the orientation of topographical features, wall shear stress gradients act in a synergistic or antagonistic manner to topography in promoting a guided morphological cell response. Towards this scope ultra-fast lasers as tools for 3D structuring were used. The laser fabricated substrates presented here could be used as model scaffolds for the systematic exploration of the role of 3D microenvironment on cell adhesion, proliferation and differentiation, with the ultimate goal of providing mechanistic insight to guide the development of clinically relevant strategies for tissue/organ repair.

Lab Phone: (+30) 2810 39 1545
Fax: B003
Ms. Georgousi Mary

Mary joined us in September 2021 to work on a novel spectroscopy model for quantum space missions.

Mary Georgousi is a MSc student in the Space–Optics Group in IESL. She completed her undergraduate studies in Physics at the Physics Department of Aristotle University of Thessaloniki. As member of the Gravitational Waves Group – AUTh, she has worked on probing the properties of our Galaxy based on the detection of gravitational waves from LISA. She currently continues her studies in astrophysics and space applications in the Master program “Advanced Physics” in the Physics Department of University of Crete. She is also a member of SpaceDot team, participating in Fly your satellite! 3 program for CubeSats.

4TH ARCHERS WORKSHOP: HEALTH: “COMPUTATIONAL APPROACHES TO BIOLOGY AND HEALTH”
Website
Event Dates
From: 08/11/2021 15:00
To: 08/11/2021 20:30
Place
virtual

The Workshop aims to highlight the contribution of engineering and computational methods in advancing biological and health sciences. It does so by bringing together top scientists to present their research in advanced genomics, bioinformatics, biomedical engineering and neuroscience along with short presentations from four of the ARCHER fellows.

The workshop is organized in the context of ARCHERS (https://archers.iesl.forth.gr/), a major project implemented by FORTH with the exclusive donation of the Stavros Niarchos Foundation (SNF). Through ARCHERS, over 100 young doctoral students and post-doctoral researchers have been supported over the past four and a half years and have carried out cutting-edge research in the Institutes of FORTH across a broad range of interdisciplinary thematics including preservation of cultural heritage and tackling of societal challenges such as environment, clean energy and health.

3RD ARCHERS WORKSHOP: ENVIRONMENT: “ENVIRONMENTAL CHALLENGES: POLLUTION AND ECOLOGY”
Website
Event Dates
From: 04/11/2021 16:00
To: 04/11/2021 19:30
Place
virtual

The workshop aims to highlight challenges posed by environmental pollution (in air, soil and water) and ecosystem threats, as well as technologies and actions to be taken to address these challenges.

The workshop is organized in the context of ARCHERS (https://archers.iesl.forth.gr/), a major project implemented by FORTH with the exclusive donation of the Stavros Niarchos Foundation (SNF). Through ARCHERS, over 100 young doctoral students and post-doctoral researchers have been supported over the past four and a half  years and have carried out cutting-edge research in the Institutes of FORTH across a broad range of interdisciplinary thematics including preservation of cultural heritage and tackling of societal challenges such as environment, clean energy and health.

2ND ARCHERS WORKSHOP: CLEAN ENERGY: “CLEAN ENERGY CHALLENGES, WITH EMPHASIS ON HYDROGEN TECHNOLOGIES”

The workshop aims to highlight the main areas of advanced and sustainable energy science and associated technological applications. The challenges for clear energy will be discussed with special attention to hydrogen related technologies.

The workshop is organized in the context of ARCHERS (https://archers.iesl.forth.gr/), a major project implemented by FORTH with the exclusive donation of the Stavros Niarchos Foundation (SNF). Through ARCHERS, over 100 young doctoral students and post-doctoral researchers have been supported over the past four and a half  years and have carried out cutting-edge research in the Institutes of FORTH across a broad range of interdisciplinary thematics including preservation of cultural heritage and tackling of societal challenges such as environment, clean energy and health.

QUANTUM MAGNETOMETRY

Atomic-optical magnetometer has been one of the leading areas in quantum technology. In this type of magnetometer information about the magnetic field is mapped to the atomic spin state, which is prepared and monitored by light.

The main interest of our group is to exploit quantum resources such as squeezing and entanglement in order to enhance the capacity, sensitivity and speed in atomic-optical magnetometers. We aim at developing new methodological approaches and implement robust experimental procedures at the quantum interface between light and warm atomic ensembles in order to perform sensing at the ultimate limits of precision. We are also interested in practical applications of ultra-sensitive magnetometer, for instance in biomedicine or in security screening. 

Currently, we are exploring two reseach directions:

  • Spin noise spectroscopy in high density alkali atomic ensembles:  Spin-noise spectroscopy contains useful information about the spin system, allowing for the study of atomic properties without externally perturbing the system. We use Faraday rotation of off-resonant light to passively detect the spin noise in an equilibrium ensemble of room-temperature paramagnetic alkali atoms experiencing a DC magnetic field. In the regime of high alkali density and low magnetical field, strong correlations between the hyperfine levels result in previously unnoticed features in the spin noise spectrum. 
  • Simultaneous reduction of all quantum noises in an atomic-optical magnetometer: In an atomic-optical magnetometer information about the magnetic field is mapped to the atomic spin state, which is then monitored by light. These magnetometers have reached a level of sensitivity limited by quantum effects. We can identify three noise sources originating from the quantum nature of light and atoms that could potentially limit the sensitivity of the magnetometer: photon shot noise, atom shot noise (also called spin projection noise) and the back-action noise. We aim to realize a magnetometer that will address for the first time all types of quantum noise that affect an atomic-optical magnetometer and demonstrate quantum advantage in the measurement. To this end, we will use stroboscopic modulation of the probe light synchronized with the atomic spin precession, resulting in atomic-spin squeezed and light-squeezed states.

 

Quantum Enhanced Magnetometer with Squeezed Light
Quantum measurement with cold atoms

Heads

Dr. Vasilakis Giorgos
Principal Researcher

Research Associates

Dr. Mylonakis Mikis
PostDoctoral Fellow

Alumni

Ms. Koutrouli Vassiliki
Ph.D. student

Scientific space missions require an ever-increasing level of optical complexity. Beams must be split, recombined and coupled in and out of optical fibres. Modern optical platforms must include active elements such as acousto-optic and electro-optic modulators, as well as mechanical shutters. Example applications include the LISA interferometer, where optical laser beams must be prepared and controlled, or the STE-QUEST II and PHARAO atom-clock missions, where many different laser beams must be controlled in frequency and amplitude in order to cool and manipulate atomic clouds. The main challenge is that the beams must be coupled into single mode optical fibres after having traversed a number of active and passive optical elements. This can only be achieved using optical breadboard technology.

We are currently developing in colaboration with ESA novel technologies for beam steering on compact optical bread boards. The aim of the project is to simplify existing techniques whilst increasing stability and scalability.

The standard solution to reduce the effect of unavoidable thermal variations is to use a thick base-plate from an ultra-low-expansion (ULE) material such as Zerodur. One then mounts optical elements onto the base-plate using methods like Hydroxide-catalysis bonding (LISA) or UV-curable optical adhesives (MAIUS-QUANTUS). In many cases (like a beam-splitter to be glued) the vertical angle can only be adjusted by machining the optical element itself. Where precise adjustments or more complex shapes are required, currently one has to use non-ULE materials such as Invar or sapphire. The fibre couplers, for example, typically consist of in complex housings allowing both angle and position displacement. This often requires the use of non-ULE materials.

 

Current Projects

SkinUP:

The upgrade of the Skinakas Observatory for optical and quantum communication ground station, which is financed by the European Space Agency under the acronym SkinUP.

CARIOQA-PMP

CARIOQA aims to develop an Engineering Model (EM) of the mission’s instrument and to increase the Technology Readiness Level (TRL) of the critical subsystems up to 5. An EM is a light representative model in terms of form, fit and function used for the design qualification test program, it is not intended to flight. Complementary EU industrial partners develop the subsystems of the instrument (i.e. Physics Package, Laser System, Microwave Source and Ground Support Equipment) and increase its TRL by assessing the critical technologies in relevant environments. Excellent institutes bring their quantum expertise for the definition of the EM and the mastering of its performance. 

SpaceTools:

This project is developing novel space-compatible laser stabilisation tools, which are aimed at Rb-based atom quantum sensors

 

 

 

Optical Beam Steering Technology for complex space missions, European Space Agency (ESA)
Precise and robust optical beam steering for space optical instrumentation
G. Drougakis, K. G. Mavrakis, S. Pandey, G. Vasilakis, K. Poulios, D. G. Papazoglou, and W. von Klitzing
CEAS Space Journal, Volume:-, Page:1-9, Year:2019, DOI:dx.doi.org/10.1007/s12567-019-00271-x
Simple precision measurements of optical beam sizes
Mikis Mylonakis, Saurabh Pandey, Kostas G. Mavrakis, Giannis Drougakis, Georgios Vasilakis, Dimitris G. Papazoglou, and Wolf von Klitzing
OSA-AO, Volume:57, Issue:33, Page:9863-9867, Year:2018, DOI:https://doi.org/10.1364/AO.57.009863
AEDGE: Atomic Experiment for Dark Matter and Gravity Exploration in Space
Y. A. El-Neaj, et al.
EPJ Qunat. Techn., Volume:7, Issue:6, Page:1-6, Year:2020, DOI:https://doi.org/10.1140/epjqt/s40507-020-0080-0
SAGE: A proposal for a space atomic gravity explorer
Guglielmo Maria Tino, A. Bassi, G. Bianco, Kai Bongs, Philippe Bouyer, L. Cacciapuoti, S. Capozziello, X. Chen, M.L. Chiofalo, A. Derevianko, W. Ertmer, Naceur Gaaloul, P. Gill, Peter W. Graham, Jason M. Hogan, L. Iess, Mark A. Kasevich, H. Katori, C. Klempt, X. Lu, L.-S. Ma, H. Müller, N.R. Newbury, C.W. Oates, Achim Peters, N. Poli, E.M. Rasel, Gabriele Rosi, Albert Roura, C. Salomon, Stephan Schiller, Wolfgang P. Schleich, D. Schlippert, F. Schreck, Christian Schubert, Fiodor Sorrentino, U. Sterr, J.W. Thomsen, G. Vallone, F. Vetrano, Paolo Villoresi, Wolf von Klitzing, D. Wilkowski, P. Wolf, J. Ye, N. Yu, and M. Zhan
E.J.P.D, Volume:73, Issue:11, Page:228, Year:2019, DOI:https://doi.org/10.1140/epjd/e2019-100324-6
ELGAR -- a European Laboratory for Gravitation and Atom-interferometric Research
B. Canuel et al.
arXiv e-prints, Volume:1911, Page:03701, Year:2019, DOI:arxiv.org/abs/1911.03701

Heads

Dr. von Klitzing Wolf
Principal Researcher
Prof. Papazoglou Dimitrios
University Faculty Member

Students

Ms. Examilioti Pandora
Ph.D. student
Ms. Georgousi Mary
Ph.D. student

Alumni

Dr. Drougakis Giannis
Alumni
Mr. Tzardis Vangelis
M.Sc. student
Mr. Pal Deba
Technical Scientist
Mr. Thekkeppatt Premjith
M.Sc. student

RIS Crete

ΜΙΑ (1) ΘΕΣΗ ΤΕΧΝΙΚΟΥ ΣΤΟ ΠΡΟΓΡΑΜΜΑ OLIPOT
The deadline to apply for this position has expired.
Publication Date
19/10/2021
Application Deadline
03/11/2021
Position Category
Reference Number
2021_63357_
Salary
Location
Herakleion, Crete, Greece
Contact Person
Start Date
01/01/2022

Position Description

Τεχνικός Ανάλυσης Δεδομένων για την επεξεργασία μετρήσεων οπτικής φασματοσκοπίας με ανάπτυξη και εφαρμογή τεχνικών Μηχανικής Μάθησης.

  • Ανάπτυξη και εφαρμογή λογισμικού στατιστικής επεξεργασίας δεδομένων για την ανάλυση των πειραματικών αποτελεσμάτων σύμφωνα με τις απαιτήσεις του έργου
  • Διευθέτηση της προμήθειας του απαραίτητου software και hardware του εργαστηρίου
  • Διάχυση των αποτελεσμάτων του έργου (π.χ. μέσω δημοσιεύσεων σε επιστημονικά περιοδικά, παρουσιάσεων σε συνέδρια, αναρτήσεων σε κοινωνικά δίκτυα ή στην ιστοσελίδα του έργου, κ.α.)
  • Συμμετοχή σε συναντήσεις με τα μέλη του εργαστηρίου και με εξωτερικούς συνεργάτες

Related Project

OLiPoT -

Required Qualifications

  • Πτυχίο Θετικών Επιστημών (Μαθηματικών, Επιστήμης Υπολογιστών ή συναφούς αντικειμένου)
  • Μεταπτυχιακό στην Στατιστική ή Πληροφορική (ή συναφούς αντικειμένου)  
  • Γνώση σε εφαρμογές μηχανικής μάθησης, pattern recognition, neural networks για την ανάλυση και επεξεργασία πειραματικών δεδομένων με μοντέλα κατηγοριοποίησης και πρόβλεψης ιδιοτήτων με εφαρμογή σε προϊόντα αγροδιατροφής  
  • Γνώση και εμπειρία στην χρήση πακέτων λογισμικού ανάλυσης δεδομένων (π.χ. MATLAB PLS Toolbox, PYTHON κ.ά.)  
  • Τουλάχιστον 2 δημοσιεύσεις σε διεθνή επιστημονικά περιοδικά ή σε συνέδρια  

Application Procedure

Στο φάκελο υποβολής της πρότασης θα πρέπει να εμπεριέχονται τα ακόλουθα:

  • Αίτηση (Form Greek στην αριστερή στήλη) με αναφορά στον κωδικό της θέσης και στο όνομα του προγράμματος
  • Αναλυτικό Βιογραφικό Σημείωμα
  • Ευκρινή φωτοαντίγραφα τίτλων σπουδών

 

ΥΠΟΒΟΛΗ ΠΡΟΤΑΣΕΩΝ

Οι ενδιαφερόμενοι καλούνται να υποβάλουν τις αιτήσεις τους και όλα τα απαραίτητα δικαιολογητικά, ηλεκτρονικά στη διεύθυνση hr@iesl.forth.gr με κοινοποίηση (cc): στον Δρ Μ. Βελεγράκη (vele@iesl.forth.gr). Οι αιτήσεις θα πρέπει να αποσταλούν με την ένδειξη: «Αίτηση στο πλαίσιο του προγράμματος OLiPoT, της πρόσκλησης εκδήλωσης ενδιαφέροντος με Α.Π. … και κωδικό θέσης … » (όπως αυτός αναφέρεται στον Πίνακα του Παραρτήματος). 

Appointment Duration

12 μήνες

Funding

Pages