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Dr. Filippidis George
Senior application Scientist

Dr George Filippidis is a Senior Staff Scientist at IESL-FORTH in charge of the non-linear microscopy (NLM) group. He received his B.Sc. degree from the Physics Department of the University of Crete in 1995 and his Doctorate degree from the Medical School of the same University in 2000. He performed his post doctoral studies at IESL-FORTH. His research group activities include the in vivo elucidation of molecular mechanisms and biological processes by employing various spectroscopic techniques with emphasis on advanced microscopic modalities, optical characterization of tissue, nanosurgery and the implementation of non-linear image contrast modalities (MPEF, SHG, PSHG, THG) as novel diagnostic tools for Cultural Heritage studies. He has published 70 articles in international peer-reviewed journals, 31 full-length articles in edited peer-reviewed volumes, 28 conference proceedings and 3 book chapters (Web of Science, h index 23). He was co supervisor in 3 PhD, 8 masters and 10 diploma theses from the Physics Department of the University of Crete and Aristotle University of Thessaloniki. He is co-author in 1 patent. He has given 3 invited talks in international conferences, a plenary talk and an invited internet lecture at Max-Born Institute.


  • 2000 Ph.D. in Biophysics, University of Crete
  • 1995 B.Sc. in Physics, University of Crete


  • 11/2022 - present Senior Staff Scientist (ELE A) at I.E.S.L. - F.O.R.T.H.
  • 4/2017 -10/2022 Principal Staff Scientist (ELE Β) at I.E.S.L. - F.O.R.T.H.
  • 1/2007 – 3/2017 Research Scientist (permanent position) and Group Leader, Non Linear Microscopy Lab, I.E.S.L. - F.O.R.T.H.
  • 1/2002 – 12/2006 Research Associate at I.E.S.L. – F.O.R.T.H.
  • 3/2000-12/2001 Compulsory National Service (petty officer Greek Navy)
  • 6/1996 – 3/2000 Laboratory Assistant, Biomedical Applications Group, I.E.S.L. FO.R.T.H.


  • Biophotonics
  • imaging
  • microscopy
  • spectroscopy
Combined multiphoton fluorescence microscopy and photoacoustic imaging for stratigraphic analysis of paintings
G.J. Tserevelakis, V. Tsafas, K. Melessanaki, G. Zacharakis G. Filippidis
Optics Letters, Volume:44, Page:1154-1157, Year:2019, DOI:
Third Harmonic Generation microscopy distinguishes malignant cell stage in human breast tissue biopsies
E. Gavgiotaki, G. Filippidis, V. Tsafas, S. Bovasianos, G. Kenanakis, V. Georgoulias, M. Tzardi, S. Agelaki, I. Athanassakis
Scientific Reports, Volume:10, Page:11055, Year:2020, DOI:
Non-linear microscopy: a well-established technique for biological applications towards serving as a diagnostic tool for in situ Cultural Heritage studies
M. Mari, G. Filippidis
Sustainability, Volume:12, Page:1409, Year:2020, DOI:10.3390/su12041409
Polarization-dependent Second-Harmonic Generation for collagenbased staging of breast cancer
V. Tsafas, E. Gavgiotaki, M. Tzardi, E. Tsafa, C. Fotakis, I. Athanassakis, G. Filippidis
J. of Biophotonics, Volume:13, Page:e202000180, Year:2020, DOI:
Monitoring aging-associated structural alterations in Caenorhabditis elegans striated muscles via polarization-dependent second-harmonic measurements
V. Tsafas, K. Giouroukou, K. Kounakis, M. Mari, C. Fotakis, N. Tavernarakis, G. Filippidis,
J. of Biophotonics, Volume:14, Page:e202100173, Year:2021, DOI:
Application of a deep-learning technique to non-linear images from human tissue biopsies for shedding new light on breast cancer diagnosis
V. Tsafas, I. Oikonomidis, E. Gavgiotaki, E. Tzamali, G. Tzedakis, C. Fotakis, I. Athanassakis, G. Filippidis,
IEEE Journal of Biomedical and Health Informatics, Volume:28, Page:1188-1195 , Year:2022, DOI:10.1109/JBHI.2021.3104002
Comparison between Cylindrical, Trigonal, and General Symmetry Models for the Analysis of Polarization-Dependent Second Harmonic Generation Measurements Acquired from Collagen-Rich Equine Pericardium Samples
M. Mari, V. Tsafas, D. Staraki, C. Fotakis, G. Filippidis
Photonics, Volume:9, Page:254, Year:2022, DOI: photonics9040254