Plasmo-photonic sensing platforms offer a compelling pathway toward highly sensitive, miniaturized, and fully integrable bio-chemical detection systems. By combining the strong electromagnetic confinement of plasmonic nanostructures with the low-loss propagation and multiplexing capabilities of dielectric photonic integrated circuits, these hybrid architectures substantially enhance light–matter interaction while preserving scalability and on-chip functionality. In this seminar, I will present the theoretical framework, device design methodologies, and experimental implementation of plasmo-photonic sensors based on both interferometric and resonant configurations, including double-arm (Mach–Zehnder) interferometers, Bragg-assisted cavities, and single-arm bimodal waveguide structures. Emphasis will be placed on engineering sensitivity beyond conventional evanescent-field limitations, analyzing performance trade-offs and optimizing key performance indicators.