The development of micro-electronic devices that bridge the gap between the rigidity of traditional electronics with the soft mechanics of biological systems is highly desirable. A recent example of a bio-integrated electronic device, the BiOET, is based on polymeric semiconductor technology and is fabricated using nano/micro-fab methods in conjunction with synthetic biology approaches to incorporate hierarchically organized biological models of the cell membrane. Despite their significance, cell membranes are still an underexplored target for studying the mechanisms of diseases or drug therapies. Cell-free commercially available technologies for cell membrane studies have been limited to synthetic membranes that lack the inherent complexity found in the membrane of the cell. In this talk I will describe a method to create native cell membrane models using vesicles derived from live cells. The vesicles fuse on top of conducting polymer- based microfabricated electrodes and transistors. The hydrogel-like surface of conducting polymers provides a fluid environment close to the physiologically relevant one, facilitating mobility (hence function) of transmembrane proteins. The activity of transmembrane proteins in response to different stimuli can be electrically monitored, offering a physiologically relevant alternative to using whole cells in characterising drug toxicity or potency at the critical first contact point: membrane interaction.