An overview of the Physics Dept., Electronics Lab activities and projects will be presented. One of this activities, and in particular the topic of Crosstalk in mixed-signal System on Chip will be addressed. Coupling occurs between noise transmitters, which are usually fast switching digital blocks and noise receivers, which are sensitive analog / RF blocks, and it takes place due to the conductive nature of the silicon substrate, the devices interface and  the  Chip - package interaction. In this presentation, the SoC crosstalk degradation phenomenon is presented and challenges and limitations are addressed versus  the  design methodology.