Whole Animal Imaging


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Fluorescence Molecular Tomography for in-vivo imaging in small animal (mice), mainly for Immunology studies.

Research Topics
In-vivo Optical Imaging



Collaborators

Inside FORTH:

  • Clio Mamalaki (IMBB)
  • Ana Sarasa-Renedo
  • Rosy Favicchio

Outside FORTH:

  • Anna Planas, Abraham Martin: IDIBAPS, http://www.idibaps.ub.edu/eng/home.php
  • Juan Aguirre, Manuel Desco, Juanjo Vaquero: HGGM, http://image.hggm.es
  • Florian Stuker, Markus Rudin: ETH, http://www.biomed.ee.ethz.ch/people/rudinma
  • Vasilis Ntziachristos, TUM, http://www.helmholtz-muenchen.de/en/ibmi/research/medical-imaging/index.html

Publications

  • Scanning illumination-acquisition system for non-contact optical tomography
    Ignacio Iglesias and Jorge Ripoll, Journal of Biomedical Optics, 14, 024003, 2009

  • In vivo optical tomography: From diffusion to ballistic
    Ripoll J, Meyer H, and Garofalakis A, Optical Materials, 31, 1082, 2009

  • Investigating pharmacology in vivo using magnetic resonance and optical imaging
    Jorge Ripoll, Vasilis Ntziachristos, Catherine Cannet, Rainer Kneuer, Hans-Ulrich Gremlich, and Nicolau Beckmann, Drugs in Research and Development, 9, 277, 2008

  • Non-invasive in vivo assessment of stroke-induced immune depression by three-dimensional fluorescence molecular tomography in transgenic mice expressing GFP in T-lymphocytes
    Abraham Martin, Juan Aguirre , Ana Sarasa, Anikitos Garofalakis, Heiko Meyer, Clio Mamalaki, Jorge Ripoll and Anna M. Planas, Molecular Imaging, 7, 157, 2008

  • Three-dimensional in vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography
    A. Garofalakis, G. Zacharakis, H. Meyer, E. N. Economou, C. Mamalaki, J. Papamatheakis, D. Kioussis, V. Ntziachristos, and J. Ripoll, Molecular Imaging, 6, 96, 2007

  • Noncontact optical imaging in mice with full angular coverage and automatic surface extraction
    H. Meyer, A. Garofaiakis, G. Zacharakis, S. Psycharakis, C. Mamalaki, D. Kioussis, E. N. Economou, V. Ntziachristos, and J. Ripoll, Applied Optics, 46, 3617, 2007

  • From finite to infinite volumes: Removal of boundaries in diffuse wave imaging
    J. Ripoll and V. Ntziachristos, Physical Review Letters, 96, 173903, 2006

  • Diffuse photon propagation in multilayered geometries
    J. Sikora, A. Zacharopoulos, A. Douiri, M. Schweiger, L. Horesh, S.R. Arridge, and J. Ripoll, Physics in Medicine and Biology, 51, 497, 2006

  • Image Analysis for Assessing Molecular Activity Changes in Time-Dependent Geometries
    K. Marias, J. Ripoll, H. Meyer,V. Ntziachristos, and S. Orphanoudakis, IEEE Transactions on Medical Imaging , 24, 894, 2005

  • Accuracy of fluorescent tomography in presence of heterogeneities: Study of the normalized Born ratio
    A. Soubret, J. Ripoll and V. Ntziachristos, IEEE Transactions on Medical Imaging , 24, 1377, 2005

  • Optical characterization of thin female breast biopsies based on the reduced scattering coefficient
    A. Garofalakis, G. Zacharakis, G. Filippidis, E. Sanidas, D. D. Tsiftsis, E. Stathopoulos, M. Kafousi, J. Ripoll, and T. G. Papazoglou, Physics in Medicine and Biology, 50, 2583, 2005

  • Volumetric tomography of fluorescent proteins through small animals in vivo
    G. Zacharakis, H. Kambara, H. Shih, J. Ripoll, J. Grimm, Y. Saeki, R. Weissleder, and V. Ntziachristos, Proceedings of the National Academy of Sciences of the United States of America, 102, 18252, 2005

  • Looking and listening to light: the evolution of whole-body photonic imaging
    V. Ntziachristos, J. Ripoll, L. H.V. Wang, and R. Weissleder, Nature Biotechnology, 23, 313, 2005

  • Experimental determination of photon propagation in highly absorbing and scattering media
    J. Ripoll, D. Yessayan, G. Zacharakis, and V. Ntziachristos, Journal of the Optical Society of America A, 22, 546, 2005

  • Volumetric tomography of fluorescent proteins through small animals in vivo
    G. Zacharakis, H. Kambara, H. Shih, J. Ripoll, J. Grimm, Y. Saeki, R. Weissleder, and V. Ntziachristos, Proc. Natl. Acad Sci USA, 102, 18252, 2005

  • Planar fluorescence imaging using normalized data
    V. Ntziachristos, G. Turner, J. Dunham, S. Windsor, A. Soubret, J. Ripoll and H.A. Shih, Journal of Biomedical Optics, 10, 064007, 2005

  • Imaging scattering media from a distance: Theory and applications of noncontact optical tomography
    J. Ripoll and V. Ntziachristos, Modern Physics Letters B, 18, 1403, 2004

  • Experimental fluorescence tomography of tissues with noncontact measurements
    R.B. Schulz, J. Ripoll, and V. Ntziachristos, IEEE Transactions on Medical Imaging , 23, 492, 2004

  • Visualization of treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate
    V. Ntziachristos, E.A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A.Jr. Bogdanov, L. Josephson, and R. Weissleder, Proc. Natl. Acad Sci USA, 101, 12294, 2004

  • Optical characterization of thin scattering samples
    A. Garofalakis, G. Zacharakis, G. Filippidis, V. Ntziachristos, E. Sanidas, D. D. Tsiftsis, T. G Papazolgou and J. Ripoll, Journal of Optics A-Pure and Applied Optics, 6, 725, 2004

  • In vivo continuous-wave optical breast imaging enhanced with Indocyanine Green
    X. Intes, J. Ripoll, Y. Chen, S. Nioka, A.G. Yodh, and B. Chance, Medical Physics, 30, 1039, 2003

  • Free-space propagation of diffuse light: Theory and experiments
    J. Ripoll, R.B. Schulz, and V. Ntziachristos, Physical Review Letters, 91, 103901, 2003

  • An iterative boundary reflection method for diffuse optical tomography
    J. Ripoll and V. Ntziachristos, Journal of the Optical Society of America A, 20, 1103, 2003

  • Noncontact optical tomography of turbid media
    R. Schultz, J. Ripoll, and V. Ntziachristos, Optics Letters, 28, 1701, 2003

  • Singular Value Analysis and Optimization of Experimental Parameters in Fluorescence Molecular Tomography
    E. Graves, J.P. Culve, J. Ripoll, E. Weissleder and V. Ntziachristos, Journal of the Optical Society of America A, 21, 231, 2003

  • Fluorescence-mediated molecular tomography resolves protease activity in vivo
    V. Ntziachristos, C. Tung, C. Bremer C, and R. Weissleder, Nature Medicine, 8, 757, 2002

  • In vivo tomographic imaging of near-infrared fluorescent probes
    V. Ntziachristos, C. Bremer, E.E. Graves, J. Ripoll, and R. Weissleder, Molecular Imaging, 1, 82, 2002

  • Would near-infrared fluorescence signals propagate through large human organs for clinical studies?
    V. Ntziachristos, J. Ripoll, and R. Weissleder, Optics Letters, 27, 333, 2002

  • A fast analytical approximation for arbitrary geometries in diffuse optical tomography
    J. Ripoll, M. Nieto-Vesperinas, R. Weissleder, and V. Ntziachristos, Optics Letters, 27, 527, 2002

Project Members
Dr. Giannis Zacharakis



Last Updated:  16/11/2009
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