In-vivo Optical Imaging

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Our research activities concern the design, development and application of tomographic technologies for in-vivo imaging in living systems. We are interested in the noninvasive visualization of specific molecular targets and pathways by exploiting the fluorescence signal emitted by fluorescent probes attached to cells or molecules. An important aspect of our research concerns the analysis of images obtained by the system and representing three-dimensional maps of fluorescent concentration in whole animals. This technique, which is called Fluorescence Molecular Tomography (FMT) can measure and characterize specific molecular processes, and thus answers can be given in particular biological questions concerning disease development, cell function, gene expression and drug delivery. Similar approaches are also being implemented by the group towards microscopy imaging by using Optical Projection Tomography (OPT) to image in-vivo at the sub mm range. In addition, theoretical research concerning the development of novel theoretical tools for the accurate modeling of light propagation in tissue-like media is one of the key developments of the group.


Contact Person(s):
Dr. Giannis Zacharakis

Last Updated:  29/1/2014