The main
goal of the Probe Development subproject is the development of novel fluorescent
probes and sensors with a large range of wavelengths. Particular aims are:
|
Biology (IMBB) |
Efforts will be concentrated in understanding the basics of confocal microscopy, use of a 3D in-vivo optical tomographer and a multi-purpose scanning laser microscope to study:
|
B.1) |
Molecular mechanisms underlying sensory transduction (mechanical chemical and temperature stimuli) in simple model organisms amenable to genetics, such as C. elegans. Molecular mechanisms involved in neurodegenerative cell death and ageing. |
|
B.2) |
Drosophila developmental biology: Molecular mechanisms of cell intersctions underlying developmental decisions in Drosophila |
|
B.3) |
Developmental and functional Biology in Mammals (cell trafficking with fluorescent probes) |
|
B.4) |
Imaging of developmental and functional Biology in Mammals |
|
B.5) |
Imaging of Transcription regulation |