The main goal of the Probe Development subproject is the development of novel fluorescent probes and sensors with a large range of wavelengths. Particular aims are:

 Biology (IMBB)

Efforts will be concentrated in understanding the basics of confocal microscopy, use of  a 3D in-vivo optical tomographer and a multi-purpose scanning laser microscope to study:

B.1)

Molecular mechanisms underlying sensory transduction (mechanical chemical and temperature stimuli) in simple model organisms amenable to genetics, such as C. elegans. Molecular mechanisms involved in neurodegenerative cell death and ageing.

B.2)

Drosophila developmental biology: Molecular mechanisms of cell intersctions underlying developmental decisions in Drosophila

B.3)

Developmental and functional Biology in Mammals (cell trafficking with fluorescent probes)

B.4)

Imaging of developmental and functional Biology in Mammals

B.5)

Imaging of Transcription regulation